> ## Documentation Index
> Fetch the complete documentation index at: https://docs-evisyn.grabmywork.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Meta-Analysis

> Forest plots, effect sizes, and risk of bias visualization

For quantitative synthesis, EviSyn provides built-in meta-analysis with forest plot generation, data extraction from papers, and risk of bias integration.

## Creating a Meta-Analysis

Navigate to **Meta-Analysis** from your project dashboard and click **New Analysis**.

### Step 1: Topics & Groups

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/meta-analysis-setup.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=24665b5c48e1c42188b937852ebceaae" alt="Meta-analysis setup wizard" width="1882" height="1762" data-path="images/meta-analysis-setup.png" />

Configure your analysis:

| Field              | Description                                                        |
| ------------------ | ------------------------------------------------------------------ |
| **Analysis Topic** | What you're comparing (e.g., "ICU Stay after lung cancer surgery") |
| **Description**    | Optional details about the analysis                                |
| **Group 1**        | Intervention group label (e.g., "Favours Prehabilitation")         |
| **Group 2**        | Control group label (e.g., "Favours Standard of Care")             |
| **Outcome Type**   | Continuous or Binary                                               |
| **Effect Measure** | SMD, MD, OR, RR, etc.                                              |
| **Model**          | Fixed Effect or Random Effects                                     |

Click **Next** to proceed.

### Step 2: Columns

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/meta-analysis-columns.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=60a1d75c4e2405e2690f6fd79f7c42e4" alt="Column configuration" style={{ maxWidth: '400px' }} width="756" height="1070" data-path="images/meta-analysis-columns.png" />

Columns are auto-populated based on your outcome type and effect measure:

* **Study** — Study identifier
* **Group 1 Mean/SD/Total** — Intervention group statistics
* **Group 2 Mean/SD/Total** — Control group statistics
* **Weight** — Study weight in the analysis
* **Std. Mean Difference** — Calculated effect size

You can rename, add, or remove columns as needed.

### Step 3: Risk of Bias

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/meta-analysis-rob.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=d7f57206eb411034c6f8efab1f83ee0d" alt="Risk of bias template selection" style={{ maxWidth: '400px' }} width="1826" height="1758" data-path="images/meta-analysis-rob.png" />

Select a risk of bias template to integrate with your analysis:

| Template                      | Description                       |
| ----------------------------- | --------------------------------- |
| **RoB 2.0 (Cochrane)**        | Standard 5-domain RoB2 assessment |
| **ROBINS-I (Non-randomized)** | For non-randomized studies        |
| **Newcastle-Ottawa Scale**    | For observational studies         |
| **Custom (start empty)**      | Build your own domains            |

Domains are displayed as columns in your analysis table.

## The Analysis Table

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/meta-analysis-table.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=d39cbf3a92938a3e6d89a362d037b775" alt="Meta-analysis data table" width="3820" height="1314" data-path="images/meta-analysis-table.png" />

The analysis table shows:

* **Study data** — Click cells to edit values directly
* **Effect sizes** — Auto-calculated based on your input
* **Risk of bias** — Color-coded traffic light indicators per domain

### Adding Studies

| Method                  | How                                              |
| ----------------------- | ------------------------------------------------ |
| **Add Papers**          | Select from your finalized papers                |
| **Extract from Papers** | AI reads papers and populates data automatically |
| **Import Template**     | Import from a pre-filled spreadsheet             |
| **Manual Entry**        | Click cells to enter data directly               |

### AI Data Extraction

Click **Extract from Papers** to have the AI read each paper and populate the meta-analysis columns:

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/meta-analysis-extract.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=1bba1b6e9e17f2e3c9366437360cae14" alt="AI extracting data into meta-analysis" width="3818" height="1038" data-path="images/meta-analysis-extract.png" />

The extraction progress bar shows which paper is being processed.

## Forest Plot

Click **Rebuild Forest Plot** to generate a publication-ready visualization.

<img src="https://mintcdn.com/ravian/YwBZFdlBbtQ_-NDF/images/forest-plot.png?fit=max&auto=format&n=YwBZFdlBbtQ_-NDF&q=85&s=7ce7060b05591b1688e012c5dd92c4be" alt="Forest plot with risk of bias" width="3822" height="1766" data-path="images/forest-plot.png" />

The forest plot shows:

* **Effect sizes** with confidence intervals for each study
* **Diamond** for the pooled effect
* **Heterogeneity statistics** (I², Q, p-value)
* **Risk of bias traffic lights** — colored circles showing RoB2 domain ratings per study
* **Overall risk of bias** column

### Export Options

| Format              | Description                                    |
| ------------------- | ---------------------------------------------- |
| **Pull RoB**        | Sync risk of bias data from quality assessment |
| **Import Template** | Import study data from spreadsheet             |
| **Export CSV**      | Download the full analysis table               |

## What's Next?

After meta-analysis, proceed to [Manuscript Writer](/user-guide/manuscript-writer) to draft your Results and Discussion sections.
